of the pulse, running up to 160 a minute. Albumin is generally present, sometimes found twenty-four hours after the use of this drug.

Golden classes chlorid of ethyl with internal poisons, and says that it must be used with the greatest care, and only in brief operations. For this reason it cannot be compared with either ether or chloroform in prolonged operations. In short operations, however, he considers it safer than chloroform, but not so safe as ethyl bromid. Both should be used with the patient in a recumbent position and with a free accompaniment of air. T. O. Allen reports one death, but does not state the number of cases in which this drug was used. The patient was a colored man, aged twenty-eight, an epileptic, who was to be operated on for inguinal hernia at the Pennsylvania Hospital. Anesthesia was started with ethyl chlorid and was used until near narcosis, when ether was substituted. At that moment the patient gagged, and vomited enormous quantities of a clear watery liquid, which seemed to flow from his mouth without any apparent retching. Both respiration and heart action ceased, and all efforts to restore them were fruitless. This death, in my opinion, however, cannot justly be laid to the use of ethyl chlorid.

In 24 cases of minor operations reported by McCardie, the longest lasting fifty-four minutes, no unpleasant effect was produced by the use of ethyl chlorid, except in one case, in which the patient died an hour afterward from heart disease, the autopsy showing advanced disease of the heart and other organs.

The whole number of cases collected by McCardie was 16,000, with but one death, and 12,436 are reported by M. W. Ware, with but one death. …”